Action on the migraine aura
THE MECHANISM PF ACTION OF 5-HTP
5-HTP is extracted from the seeds of the Griffonia simpliciofila in the form of L-Tryptophan, and it is metabolized by specific enzymes in kinurenic acid. The active compound in the kinurenic pathway, after passing through the blood-brain barrier, antagonizes the excitatory action of the glutamminergic acid in the central nervous system by blocking the activity of the NMDA receptor, that is hyperactivated during migraine attacks..
THE MECHANISM OF ACTION OF MAGNESIUM
Magnesium deficiency can cause cortical spreading depression and the phenomenon of the aura. The Mg+ is able to inhibit the activity of the NMDA receptor, mainly involved in the excitatory glutamminergic activity, which leads to neurogenic inflammation and, in the central nervous system, to the phenomenon of the aura.
THE MECHANISM OF ACTION OF TANACETUM PARTHENIUM
Tanacetum parthenium is a perennial herbaceous plant, a member of the family of compositeae. Because of its main active component, parthenolide, it is involved in the development of the aura. The activators of TRP receptors, through the release of CGRP from the perivascular terminals of sensory neurons produce neurogenic inflammation, which leads to painful crisis. This cascade of events can be blocked by Parthenolide, one of the antagonists of the TRP receptors.